sábado, 22 de mayo de 2010
Diabetes, estrés oxidativo y antioxidantes
La diabetes mellitus es un síndrome caracterizado
por la concentración elevada de glucosa sanguínea.
La enfermedad es progresiva y está asociada con
alto riesgo de ateroesclerosis, daño renal, neuronal y
ceguera; lo que la convierte en una de las principales
causas de morbi-mortalidad. Actualmente, existen
evidencias de que tales complicaciones se deben
principalmente a que se produce un desequilibrio
bioquímico propiciado por la producción excesiva
de radicales libres (RL), lo que provoca daño
oxidativo a las biomoléculas y que no puede ser
contrarrestado por los sistemas antioxidantes de
defensa. Afortunadamente, dicho daño se puede
evitar o disminuir con la administración de dosis
adecuadas de antioxidantes exógenos (suplementos
de alta calidad), lo que pudiera permitir a los
pacientes diabéticos tener mejor calidad de vida,
pues es de esperar que las complicaciones micro
y macrovasculares ocasionadas principalmente por
la producción excesiva de RL disminuyan con la
administración de los antioxidantes.
Berry anthocyanins as novel antioxidants in human health and disease prevention.
Zafra-Stone S, Yasmin T, Bagchi M, Chatterjee A, Vinson JA, Bagchi D.
Research and Development Department, InterHealth Research Center, Benicia, CA, USA.
Comment in:
Mol Nutr Food Res. 2008 Mar;52(3):386-7; author reply 388.
Edible berries, a potential source of natural anthocyanin antioxidants, have demonstrated a broad spectrum of biomedical functions. These include cardiovascular disorders, advancing age-induced oxidative stress, inflammatory responses, and diverse degenerative diseases. Berry anthocyanins also improve neuronal and cognitive brain functions, ocular health as well as protect genomic DNA integrity. This chapter demonstrates the beneficial effects of wild blueberry, bilberry, cranberry, elderberry, raspberry seeds, and strawberry in human health and disease prevention. Furthermore, this chapter will discuss the pharmacological benefits of a novel combination of selected berry extracts known as OptiBerry, a combination of wild blueberry, wild bilberry, cranberry, elderberry, raspberry seeds, and strawberry, and its potential benefit over individual berries. Recent studies in our laboratories have demonstrated that OptiBerry exhibits high antioxidant efficacy as shown by its high oxygen radical absorbance capacity (ORAC) values, novel antiangiogenic and antiatherosclerotic activities, and potential cytotoxicity towards Helicobacter pylori, a noxious pathogen responsible for various gastrointestinal disorders including duodenal ulcer and gastric cancer, as compared to individual berry extracts. OptiBerry also significantly inhibited basal MCP-1 and inducible NF-kappabeta transcriptions as well as the inflammatory biomarker IL-8, and significantly reduced the ability to form hemangioma and markedly decreased EOMA cell-induced tumor growth in an in vivo model. Overall, berry anthocyanins trigger genetic signaling in promoting human health and disease prevention.
PMID: 17533652 [PubMed - indexed for MEDLINE]
Zafra-Stone S, Yasmin T, Bagchi M, Chatterjee A, Vinson JA, Bagchi D.
Research and Development Department, InterHealth Research Center, Benicia, CA, USA.
Comment in:
Mol Nutr Food Res. 2008 Mar;52(3):386-7; author reply 388.
Edible berries, a potential source of natural anthocyanin antioxidants, have demonstrated a broad spectrum of biomedical functions. These include cardiovascular disorders, advancing age-induced oxidative stress, inflammatory responses, and diverse degenerative diseases. Berry anthocyanins also improve neuronal and cognitive brain functions, ocular health as well as protect genomic DNA integrity. This chapter demonstrates the beneficial effects of wild blueberry, bilberry, cranberry, elderberry, raspberry seeds, and strawberry in human health and disease prevention. Furthermore, this chapter will discuss the pharmacological benefits of a novel combination of selected berry extracts known as OptiBerry, a combination of wild blueberry, wild bilberry, cranberry, elderberry, raspberry seeds, and strawberry, and its potential benefit over individual berries. Recent studies in our laboratories have demonstrated that OptiBerry exhibits high antioxidant efficacy as shown by its high oxygen radical absorbance capacity (ORAC) values, novel antiangiogenic and antiatherosclerotic activities, and potential cytotoxicity towards Helicobacter pylori, a noxious pathogen responsible for various gastrointestinal disorders including duodenal ulcer and gastric cancer, as compared to individual berry extracts. OptiBerry also significantly inhibited basal MCP-1 and inducible NF-kappabeta transcriptions as well as the inflammatory biomarker IL-8, and significantly reduced the ability to form hemangioma and markedly decreased EOMA cell-induced tumor growth in an in vivo model. Overall, berry anthocyanins trigger genetic signaling in promoting human health and disease prevention.
PMID: 17533652 [PubMed - indexed for MEDLINE]
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